Photophysical and Bactericidal Properties of Pyridinium and Imidazolium Porphyrins for Photodynamic Antimicrobial Chemotherapy

Despite advances achieved over the last decade, infections caused by multi-drug-resistant bacterial strains are increasingly becoming important societal issues that need to be addressed. New approaches have already been developed in order overcome this problem. Photodynamic antimicrobial chemotherapy (PACT) could provide an alternative fight infectious bacteria. Many studies highlighted value of cationic photosensitizers improve approach. This study reports synthesis and characterization porphyrins derived from methylimidazolium phenylimidazolium porphyrins, along with a comparison their photophysical properties well-known N-methylpyridyl (pyridinium) porphyrin family. PACT tests conducted tetracationic these three families showed new may offer good classical pyridinium especially against S.aureus E.coli. In addition, they pave way means derivatization through amide bond formation.